[December 17, 2010 405 Fifth Street, NW Gentlemen: 135 South State College Boulevard, Suite 300 | Brea, California 92821 | 714.990.1040 | frazerfrost.com Los Angeles and Visalia, CA | Little Rock and Fayetteville, AR | Raleigh, NC F R AZER FROST, LLP EX-16.1 2 v205591_ex16-1.htm] [NEWS RELEASE Skystar Bio-Pharmaceutical Appoints Crowe Horwath LLP as New Independent Auditor XI’AN, CHINA – December 15, 2010 -- - Skystar Bio-Pharmaceutical Company (NASDAQ:SKBI) ("Skystar" or the "Company"), To be added to the Company's email distribution for future news releases, please send your request to skystar@grayling.com. About Crowe Horwath About Skystar Bio-Pharmaceutical Company Skystar is a China-based developer and distributor]

[December 17, 2010 405 Fifth Street, NW Gentlemen: 135 South Statellege Boulevard, Suite 300 | Brea,lifornia 92821 | 714.990.1040 | frazerfrost.com Los Angeles and Visalia, | Little Rock and Fayetteville, AR | Raleigh, NC F R AZER FROST, v205591_ex16-1.htm 2 EX-16.1] [NEWS RELEASEystar Bio-Pharmaceutical Appoints Crowe Horwath New Independent Auditor XIAN, CHINA December 15, 2010 -- -ystar Bio-Pharmaceuticalmpany (NASDAQ:SKBI) ("Skystar" or the "Company"), To beded to thempany's email distribution for future news releases, please send your request toystar@grayling.com.out Crowe Horwathoutystar Bio-Pharmaceuticalmpany]